Influence of -tocopherol and -lipoic acid on bisphenol-A-induced oxidative damage in liver and ovarian tissue of rats

Avcı B., Bahadir A., Tunçel Ö. K., Bilgici B.

TOXICOLOGY AND INDUSTRIAL HEALTH, vol.32, no.8, pp.1381-1390, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 8
  • Publication Date: 2016
  • Doi Number: 10.1177/0748233714563433
  • Journal Name: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1381-1390
  • Keywords: Bisphenol A, alpha lipoic acid, alpha tocopherol, oxidative stress, LIPID-PEROXIDATION, IN-VITRO, GLUTATHIONE-PEROXIDASE, METABOLIC ANTIOXIDANT, ALPHA-TOCOPHEROL, VITAMIN-C, EXPOSURE, NONYLPHENOL, STRESS, PARAOXONASE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Bisphenol A (BPA) is a commonly used material in daily life, and it is argued to cause oxidative stress in liver and ovarian tissue. -Lipoic acid (ALA) and -tocopherol (ATF), two of the most effective antioxidants, may play a role in preventing the toxic effect. Therefore, the purpose of this study was to examine the beneficial effects of ALA, ATF, and that of ALA + ATF combination on oxidative damage induced by BPA. Female Wistar rats were divided into five groups (control, BPA, BPA + ALA, BPA + ATF, and BPA + ALA + ATF). BPA (25 mg/kg/day), ALA (100 mg/kg/day), and ATF (20 mg/kg/day) were administered for 30 days. The levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), liver malondialdehyde (L-MDA) and glutathione peroxidase (L-GPx), and ovarian malondialdehyde (Ov-MDA) and nitric oxide (Ov-NO) were significantly higher in the BPA-treated groups compared with the control group. The levels of AST and ALT decreased in the BPA + ALA, BPA + ATF, and BPA + ALA + ATF groups compared with the BPA group. Similarly, BPA + ALA or BPA + ATF led to decreases in L-MDA and Ov-MDA levels compared with the BPA group. However, the BPA + ALA + ATF group showed a significant decrease in L-MDA levels compared with the BPA + ALA group and the BPA + ATF group. The levels of L-GPx decreased in the BPA + ATF and the BPA + ALA + ATF groups compared with the BPA group. The administration of ATF and ALA + ATF significantly decreased the Ov-NO levels. This study demonstrates that BPA causes oxidative damage in liver and ovarian tissues. ALA, ATF, or their combination were found to be beneficial in preventing BPA-induced oxidative stress.