Effect of high fat diet on the volume of liver and quantitative feature of Kupffer cells in the female rat: A stereological and ultrastructural study

Kiki I., Altunkaynak B. Z., Altunkaynak M. E., Vuraler O., Unal D., Kaplan S.

OBESITY SURGERY, vol.17, no.10, pp.1381-1388, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1007/s11695-007-9219-7
  • Journal Name: OBESITY SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1381-1388
  • Keywords: high fat diet, Kupffer cell, liver, volume, stereology, CAVALIERI PRINCIPLE, ARBITRARY PARTICLES, UNBIASED ESTIMATION, STEATOHEPATITIS, NUMBER
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: The role of Kupffer cells (KCs) in nonalcoholic; steatohepatitis (NASH) which is regarded as a major cause of cryptogenic cirrhosis of the liver was investigated using stereological methods and electron microscopy in the rat model. To our knowledge, there is no stereological study on the volume of liver, total number, numerical density, and nuclear height of KCs of liver in the female rat fed with a high fat diet (HFD) in the literature.