Effects of Oleuropein on Serum Inflammatory Cytokines and Histopathological Changes in Rats with Pancreatitis

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Caglayan K., Gungor B. B., Cinar H., Avcı B., Gur S., Arslan H. N.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.24, no.2, pp.213-218, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.17219/acem/40453
  • Journal Name: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.213-218
  • Keywords: acute pancreatitis, oleuropein, cytokines, pancreatic damage, PHENOLIC-COMPOUNDS, OLIVE, MARKERS, INJURY
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objectives. Acute pancreatitis is a severe debilitating disease with high morbidity and mortality. The severity of the disease is largely due to the actions of various inflammatory mediators. No specific therapy is indicated for AP and its treatment remains largely supportive. This study investigated the effect of oleuropein on serum inflammatory cytokines and distant organ injury in rats with acute pancreatitis induced by bile-pancreatic duct obstruction.