Can subphysiological cold application be utilized in excessive dermal scarring prophylaxis and treatment?: A promising hypothetical perspective

Yagmur C., Engin M. S., Ogawa R.

MEDICAL HYPOTHESES, vol.97, pp.4-6, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 97
  • Publication Date: 2016
  • Doi Number: 10.1016/j.mehy.2016.10.009
  • Journal Name: MEDICAL HYPOTHESES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4-6
  • Keywords: Hypertrophic scar, Keloid, Excessive dermal scarring, Cold application, Cold, Wound healing, WHOLE-BODY CRYOTHERAPY, SOFT-TISSUE INJURY, INDUCED CONSTRICTION, CUTANEOUS ARTERIES, HYPERTROPHIC SCARS, WOUND-INFECTION, TEMPERATURE, ICE, INFLAMMATION, REDUCE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Excessive dermal scarring (EDS) is a wound healing complication, characterized by protruded erythematous and inelastic 'proliferative scar tissue' which is associated with increased and prolonged inflammation process within the wound microenvironment. As inflammation plays a key role in this process, methods to contain or attenuate excessive inflammation hold promise in treatment and prophylaxis of EDS conditions.