Maternal serum screening for prenatal diagnosis of some fetal genetic disorders Bazi Fetal Genetik Hastaliklarin Prenatal Tanisinda Maternal Serum Taramasi

Malatyalioglu E., Yanik F.

Ondokuz Mayis Universitesi Tip Dergisi, vol.16, no.1, pp.76-85, 1999 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 1999
  • Journal Name: Ondokuz Mayis Universitesi Tip Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.76-85
  • Keywords: α-fetoprotein, Down's syndrome, Human chorionic gonadotropin, Neural tube defects, Triple marker, Unconjugated estriol
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Based on elevated MSAFP levels, 85% to 90% of NTDs can be detected. Using a combination of the three parameters, MSAFP, hCG and UE3, 55% to 60% of fetal Down's syndrome can be detected. Future strategies for Down's syndrome screening may include the use of new markers such as dimeric inhibin-A and urinary β-core fragment of hCG, as well as first-trimester screening, particularly with PAPP-A and free β-hCG.