Maternal serum screening for prenatal diagnosis of some fetal genetic disorders Bazi Fetal Genetik Hastaliklarin Prenatal Tanisinda Maternal Serum Taramasi

Malatyalioglu E., Yanik F.

Ondokuz Mayis Universitesi Tip Dergisi, cilt.16, sa.1, ss.76-85, 1999 (Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 1999
  • Dergi Adı: Ondokuz Mayis Universitesi Tip Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.76-85
  • Anahtar Kelimeler: α-fetoprotein, Down's syndrome, Human chorionic gonadotropin, Neural tube defects, Triple marker, Unconjugated estriol
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Based on elevated MSAFP levels, 85% to 90% of NTDs can be detected. Using a combination of the three parameters, MSAFP, hCG and UE3, 55% to 60% of fetal Down's syndrome can be detected. Future strategies for Down's syndrome screening may include the use of new markers such as dimeric inhibin-A and urinary β-core fragment of hCG, as well as first-trimester screening, particularly with PAPP-A and free β-hCG.