Synthesis, characterization, antioxidant, antibacterial and enzyme inhibitor evaluation of new furan-tethered 1,3,4-thiazoles

Muğlu H., Ibrahım M. A. K., Yakan H., Taş Ö., Bilir G., Aksakal ., ...Daha Fazla

REVUE ROUMAINE DE CHIMIE, cilt.71, sa.3-4, ss.155-168, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71 Sayı: 3-4
  • Basım Tarihi: 2026
  • Doi Numarası: 10.33224/rrch.2026.71.3-4.01
  • Dergi Adı: REVUE ROUMAINE DE CHIMIE
  • Derginin Tarandığı İndeksler: Applied Science & Technology Source, Scopus, Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.155-168
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Novel furan-tethered 1,3,4-thiadiazoles (1-5) were prepared and  characterized by FT-IR, 1H NMR, 13C NMR and elemental analysis. 

Compounds, in general, showed antibacterial effects on selected  bacteria, including K. pneumoniae, E. faecium, S. epidermidis, S. 

macrescens, B. subtilis, E. coli, and S. kentucky. Besides, none of the compounds had effects on P. aeruginosa. In vitro antioxidant 

activity determination was carried out using the DPPH method, and results of the synthesized compounds were found to be close to each 

other showing lower antioxidant activity than the standard used (ascorbic acid). In vitro acetylcholinesterase (AChE) and 

butyrylcholinesterase (BChE) inhibition of the synthesized compounds was performed using Ellman's spectrophotometry method. The 

compounds showed inhibition with IC50 values ranging from 27.39 to 45.71 µM for AChE and 13.35 to 115.17 µM for BChE. Among the 

synthesized derivatives, compound 2 exhibited the strongest inhibitory effect against both AChE, and BChE.