Investigation of the relation between anaerobic bacteria genus clostridium and late-onset autism etiology in children

Keşli R., Gökçen C., Buluǧ U., Terzi Y.

Journal of Immunoassay and Immunochemistry, vol.35, no.1, pp.101-109, 2014 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1080/15321819.2013.792834
  • Journal Name: Journal of Immunoassay and Immunochemistry
  • Journal Indexes: Scopus
  • Page Numbers: pp.101-109
  • Keywords: anaerobic bacteria, autism, etiology, gas-chromatography mass-spectrometry
  • Ondokuz Mayıs University Affiliated: Yes


The aim of this study was to investigate the relation between the etiology of late-onset childhood autism and anaerobic bacteria. Thirty children diagnosed with autistic disorder and control group have been included in the study. 3-(3-hydroxy phenyl)-3-hydroxypropionic acid (HPHPA) excretion rates which is a metabolic product of the genus Clostridium, were measured via mass spectrometry-gas chromatography (MS-GC) method from urine samples. When the assayed average HPHPA values compared with each group, a statistically significant difference was found (p < 0.05). Data obtained from this study support the existence of a significant correlation between autism etiology and anaerobic bacteria. © 2014 Taylor and Francis Group, LLC.