Crystal structure and Hirshfeld surface analysis of 3-(hydroxymethyl)-3-methyl-2,6-diphenylpiperidin-4-one
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, vol.78, pp.29-37, 2022 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 78
- Publication Date: 2022
- Doi Number: 10.1107/s2056989021012640
- Journal Name: ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
- Page Numbers: pp.29-37
- Keywords: crystal structure, piperidone, benzaldehyde, 4-hydroxy-3-methyl-2-butanone, ammonium acetate, Hirshfeld surface, hydrogen bonding
- Open Archive Collection: AVESIS Open Access Collection
- Ondokuz Mayıs University Affiliated: Yes
Abstract
A new synthesis of the title compound, C19H21NO2, was developed with good yield and purity using the reaction of 4-hydroxy-3-methyl-2-butanone, benzaldehyde and ammonium acetate in glacial acetic acid as a solvent. The central piperidine ring adopts a chair conformation, and its least-squares basal plane forms dihedral angles of 85.71 (11) and 77.27 (11)degrees with the terminal aromatic rings. In the crystal, the molecules are linked by O-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds into double ribbons. The Hirshfeld surface analysis shows that the most important contributions are from H center dot center dot center dot H (68%), C center dot center dot center dot H/H center dot center dot center dot C (19%) and O center dot center dot center dot H/H center dot center dot center dot O (12%) interactions.