ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.60, no.1, pp.79-83, 2013 (SCI-Expanded)
Article / Review
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Neurodegenerative diseases, neurosteroid, INDUCED CELL-DEATH, TRAUMATIC BRAIN-INJURY, CHAIN CLEAVAGE ENZYME, PREGNENOLONE SULFATE, 3-BETA-HYDROXYSTEROID DEHYDROGENASE, DEHYDROEPIANDROSTERONE DHEA, PROGESTERONE CONCENTRATION, AROMATASE EXPRESSION, HIPPOCAMPAL-NEURONS, MULTIPLE-SCLEROSIS
Ondokuz Mayıs University Affiliated:
Steroid synthesized from cholesterol in the central nervous system independently of gonads and adrenal glands has been defined as neurosteroids. Neurosteroids are synthesized in many species of vertebrate and invertebrate nervous systems. Neurosteroids affects the many brain functions. The expression of enzymes catalyzing the synthesis of neurosteroids and the neurosteroid levels are changes in diseases of the nervous system. It has been well documented that neurosteroids protective role on the neurons. Neurosteroids reduces the disorders associated with nervous system in neurodegenerative diseases and can be used as preventive and therapeutic in these diseases.