A new strategy in treatment of neurodegenerative diseases: Neurosteroids

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Yarım G. F.

ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.60, no.1, pp.79-83, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 60 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1501/vetfak_0000002557
  • Journal Name: ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.79-83
  • Keywords: Neurodegenerative diseases, neurosteroid, INDUCED CELL-DEATH, TRAUMATIC BRAIN-INJURY, CHAIN CLEAVAGE ENZYME, PREGNENOLONE SULFATE, 3-BETA-HYDROXYSTEROID DEHYDROGENASE, DEHYDROEPIANDROSTERONE DHEA, PROGESTERONE CONCENTRATION, AROMATASE EXPRESSION, HIPPOCAMPAL-NEURONS, MULTIPLE-SCLEROSIS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Steroid synthesized from cholesterol in the central nervous system independently of gonads and adrenal glands has been defined as neurosteroids. Neurosteroids are synthesized in many species of vertebrate and invertebrate nervous systems. Neurosteroids affects the many brain functions. The expression of enzymes catalyzing the synthesis of neurosteroids and the neurosteroid levels are changes in diseases of the nervous system. It has been well documented that neurosteroids protective role on the neurons. Neurosteroids reduces the disorders associated with nervous system in neurodegenerative diseases and can be used as preventive and therapeutic in these diseases.