Investigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicity

Cengiz N., Kavak S., Guzel A., Ozbek H., Bektaş H., Him A., ...Daha Fazla

JOURNAL OF MEMBRANE BIOLOGY, cilt.246, sa.1, ss.1-6, 2013 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 246 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00232-012-9494-7
  • Dergi Adı: JOURNAL OF MEMBRANE BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-6
  • Anahtar Kelimeler: Carbon tetrachloride, Histology, Liver, Rat, Sesame, Sesamum indicum L., ALT, AST, ALP, ANTIOXIDANT ENZYMES, LIPID-PEROXIDATION, OXIDATIVE STRESS, SERUM
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

More than 600 chemicals can cause damage in liver, one of which is carbon tetrachloride (CCl4). Hepatoprotective agents could prevent tissue damage and reduce morbidity and mortality rates; such agents may include alternative or folkloric treatments. We investigated sesame (Sesamum indicum L.) for its hepatoprotective effect in CCl4-induced experimental liver damage. To this end, 0.8 mg/kg of sesame fixed oil was provided intraperitoneally to rats whose livers were damaged by CCl4. Tissue and blood samples were taken at the end of the experiments and evaluated histologically and biochemically. Ballooning degenerations and an increase in lipid droplets in liver parenchyma and increases in serum alanine transaminase, aspartate transaminase, and bilirubin were found in the CCl4 group. Biochemical and histopathological findings in the sesame fixed oil treated group were not significantly different from the CCl4 group. Sesame did not show a hepatoprotective effect in CCl4-induced liver toxicity.