SUBCHRONIC TOXICITY AND NEUROBEHAVIOURAL EFFECTS OF ALPHACYPERMETHRIN IN RATS

Yavuz O., Kayir H., Yilmaz I., Ulusoy G., Cakir G., Macit E., ...More

FRESENIUS ENVIRONMENTAL BULLETIN, vol.18, no.8, pp.1417-1423, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 8
  • Publication Date: 2009
  • Journal Name: FRESENIUS ENVIRONMENTAL BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1417-1423
  • Keywords: Alphacypermethrin, subchronic toxicity, neurobehavioural changes, rat, ETHANOL WITHDRAWAL, WISTAR RATS, NEUROTOXICITY, CYPERMETHRIN, MICE, INSECTICIDES, EXPOSURE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Alphacypermethrin is a highly active pyrethroid insecticide effective against a wide range of pests in agriculture, public health and animal husbandry. In this study, doses of 4, 8, 16 and 32 mg/kg alphacypermethrin were prepared in corn oil (10%) and orally administered to four experimental groups (n = 10; 5 male and 5 female in each group) by gavage once daily for 90 days. Mortality and clinical findings together with behavioural changes in rats were observed daily, weekly and monthly during the study period.