Crystallographic and spectroscopic insights into a new bromo-Schiff base with antibacterial activity

Creative Commons License

Türköz Karakullukçu N.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1349, sa.143560, ss.1-9, 2025 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1349 Sayı: 143560
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.molstruc.2025.143560
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.1-9
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

A novel bromo-substituted Schiff base, (E)-4-bromo-2-(((3-hydroxy-4-methylphenyl)imino)methyl)phenol

(B-HMPIMP), was synthesized through a condensation reaction of 5-bromo-2-hydroxybenzaldehyde and 5-

amino-2-methylphenol in methanol. The compound was characterized using spectroscopic techniques

including UV–Vis, FT–IR, and NMR (1H and 13C), which confirmed the presence of imine (-C=N), hydroxyl

(-OH), aromatic, and bromo functionalities. Crystallographic analysis via single-crystal X-ray diffraction revealed

that B-HMPIMP crystallizes in the orthorhombic system with notable planarity and intramolecular hydrogen

bonding. The compound’s antibacterial potential was evaluated against Gram-positive and Gram-negative bacterial

strains, showing moderate inhibitory activity, particularly against Klebsiella pneumoniae and Staphylococcus

aureus. These findings point out the importance of B-HMPIMP as a halogenated Schiff base with both structural

stability and promising antimicrobial activity.