SYNTHESIS, CRYSTAL STRUCTURE AND ANTIOXIDANT POTENTIAL OF DI-(N-CINNAMYL) FLUOXETINE CHLORIDE

Kanwal N., Sahin O., Husaain E. A., Khan I. U., Buyukgungor O.

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, vol.58, no.1, pp.1508-1512, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.4067/s0717-97072013000100001
  • Journal Name: JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1508-1512
  • Keywords: Fluoxetine, Derivative, Crystal structure, Antioxidant activity, PHARMACOKINETICS, HYDROCHLORIDE, INHIBITION, CHANNELS, CAPACITY
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

A new derivative of Fluoxetine, N,N-dicinnamyl-N-methyl-3-phenyl-3-[4-(trifluoromethyl) phenoxy] butan-1-aminium chloride hydrate [Di-(N-Cinnamyl) Fluoxetine Chloride hydrate] was synthesized and characterized by single-crystal X-ray diffraction studies, elemental analyzer, thermogravimetric and FTIR spectroscopy analysis. The titled compound [C35H37ClF3NO2] crystallized in monoclinic, having unit cell parameters a = 19.155(14) A degrees, b = 9.193(5) A degrees, c = 18.596(13) A degrees and belongs to P2(1)/c space group. The molecule shows disorder of F atoms and was modeled as two different orientations. The one-dimensional crystal packing features weak C-H center dot center dot center dot pi interactions showing the formation of a chain along [001], provides stability to the crystal lattice. Antioxidant potential of Di-(N-Cinnamyl) Fluoxetine Chloride hydrate has been described and was found higher than Fluoxetine and N-Benzyl Fluoxetine.