Akademik Veri Yönetim Sistemi
NEW JOURNAL OF CHEMISTRY, cilt.44, sa.6, ss.2210-2221, 2020 (SCI-Expanded)
Three mononuclear coordination complexes of 1-butyl-2-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-benzimidazole (L), namely [CoL]Cl-2 (C1), [Co2L2]Cl-2 center dot H2O (C2) and [Zn2L2]Cl-2 (C3), have been synthesized and characterized spectroscopically. Their single-crystal X-ray diffraction analysis revealed that C1 and C2 display pseudopolymorphism. The presence of N-H center dot center dot center dot Cl and C-H center dot center dot center dot Cl hydrogen bonding in the crystal structure of C1 and C3 assists the formation of a 2D hydrogen bonded sheet and orthogonal packing [2D sheet + a pair of 1D chains], respectively, leading to supramolecular structures. A combination of N-H center dot center dot center dot Cl, C-H center dot center dot center dot Cl, O-H center dot center dot center dot Cl, and C-H center dot center dot center dot O interactions results however in a 2D corrugated hydrogen bonded sheet with inclusion of water molecules in C2. Hirshfeld surface analysis confirms that hydrogen bonding and pi-stacking contacts stabilize the crystal structures. These metal complexes display good performance towards their antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. In particular a normalized minimum inhibitory concentration as low as 6.25 mu g mL(-1) for the bacterial strains was recorded for C2. Its structure-bioactivity correlation is discussed in detail.