Purpose: To report regression of corneal stromal neovascularizations with the use of topical cyclosporine 0.05% in a corneal transplant patient performed for fungal corneal ulcer. Design Case report. Methods: A 14-year-old boy treated for fungal corneal ulceration developed 360° corneal stromal neovascularization peroperatively. Topical cyclosporine 0.05% was used to decrease the risk of rejection. Results: The neovascularizations regressed totally within 2 months and no signs of graft rejection were present at 6 months follow up. Conclusion: Topical cyclosporine 0.05% may result in regression of stromal corneal neovascularizations and help to reduce the risk of graft rejection in selected cases. © Springer Science+Business Media B.V. 2007.