Regression of severe corneal stromal neovascularization with topical cyclosporine 0.05% after penetrating keratoplasty for fungal corneal ulcer

Sonmez B., Beden Ü., Erkan D.

International Ophthalmology, vol.29, no.2, pp.123-125, 2009 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1007/s10792-007-9180-4
  • Journal Name: International Ophthalmology
  • Journal Indexes: Scopus
  • Page Numbers: pp.123-125
  • Keywords: Corneal neovascularization, Corneal transplant, Cyclosporine 0.05%, Fungal corneal ulcer
  • Ondokuz Mayıs University Affiliated: Yes


Purpose: To report regression of corneal stromal neovascularizations with the use of topical cyclosporine 0.05% in a corneal transplant patient performed for fungal corneal ulcer. Design Case report. Methods: A 14-year-old boy treated for fungal corneal ulceration developed 360° corneal stromal neovascularization peroperatively. Topical cyclosporine 0.05% was used to decrease the risk of rejection. Results: The neovascularizations regressed totally within 2 months and no signs of graft rejection were present at 6 months follow up. Conclusion: Topical cyclosporine 0.05% may result in regression of stromal corneal neovascularizations and help to reduce the risk of graft rejection in selected cases. © Springer Science+Business Media B.V. 2007.