Evaluation of apoptotic cell death on liver and kidney tissues following administration of levetiracetam during prenatal period

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TEKCAN A., Tural Ş., Elbistan M., Güvenç T., Ayas B., Kara N.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.30, no.4, pp.420-423, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 30 Issue: 4
• Publication Date: 2017
• Doi Number: 10.1080/14767058.2016.1174990
• Journal Name: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.420-423
• Keywords: Apoptosis, kidney, levetiracetam, liver, prenatal exposure, TUNEL assay, EPILEPSY, PREGNANCY, WOMEN, LYMPHOCYTES, MANAGEMENT, INJURY, RISKS, DRUGS
• Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: Levetiracetam is a new generation antiepileptic drug used in treatment of patients with epilepsy and has adverse effects on different tissues. We aimed to evaluate the apoptotic effects of levetiracetam exposure during pregnancy on liver and kidney tissues of rat pups.