The aim of this study is to evaluate the parameters such as pH, dissolved oxygen, temperature, conductivity, salinity, biological oxygen demand (BOD), total suspended solid, ammonia, chlorophyll-a and heavy metals affecting total coliform values in seawater using Artificial Neural Network (ANN) modelling at the Eastern Black Sea coast of Turkey. The results obtained from ANN model were compared with actual total coliform values. The samples were taken from the different points selected along the deep sea discharge systems starting from the diffuser end of three domestic deep sea discharge systems at Turkey's Eastern Black Sea coast. ANN model was developed for estimating the relationship between total coliform and other parameters. The parameters measured in seawater samples were analyzed by using the ANN model for prediction of coliform values. The results showed that neural network model is capable of estimating the sea pollution with a reasonable accuracy.