MOLECULES, vol.25, no.20, 2020 (SCI-Expanded)
Article / Article
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one-pot cascade reactions, 1, 3-dipolar cycloaddition, ionic liquid, selectivity, spirooxindole–, pyrrolidines, IONIC LIQUIDS, RING, CYCLOADDITION, DERIVATIVES, CATALYSIS
Ondokuz Mayıs University Affiliated:
Our synthetic approach for the assembly of structurally complex spirooxindole heterocyclic hybrids was based on an ionic liquid, [bmim]Br mediated one-pot three-component cascade reaction strategy involving 1,3-dipolar cycloaddition reaction of N-1-(2-pyridinylmethyl)-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones and azomethine ylide generated in situ from isatin and L-phenyl alanine, affording a series of spirooxindole-pyrrolidine heterocyclic hybrids in good-to-excellent yields. In addition to serving as the reaction medium, [bmim]Br also functioned as a catalyst in this cycloaddition reaction and hence accelerated the reaction rate affording the cycloadducts in short reaction time.