Comparison of Sugammadex and Neostigmine in Reversal of Rocuronium Induced Neuromuscular Blockade in Infants İnfantlarda Roküronyum İndüksiyonuyla Yapılan Nöromuskuler Blokajın Geri Çevrilmesinde Sugammadeks ile Neostigminin Karşılaştırılması
Anestezi Dergisi, cilt.34, sa.2, ss.127-132, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.54875/jarss.2026.32659
- Dergi Adı: Anestezi Dergisi
- Derginin Tarandığı İndeksler: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO)
- Sayfa Sayıları: ss.127-132
- Anahtar Kelimeler: Anesthesia, infant, neostigmine, recurarization, sugammadex
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Objective: Rapid postoperative recovery is of great importance in children who undergo elective surgery, but the complications encountered in the process of recurarization in these cases are crucial. The present study aims to compare the effects of sugammadex and neostigmine on the reversal of neuromuscular block and recovery in infants. Method: A total of 50 patients aged between 1 month and 12 months, American Society of Anesthesiologists (ASA) I-II class, who were to undergo elective operation were included in the study. Patients under general anesthesia were administered rocuronium IV at induction and monitored with train of four (TOF). At the end of surgery, 2 mg kg-1 sugammadex was administered to patients in sugammadex group (Group S) and 0.05 mg kg-1 neostigmine + 0.02 mg kg-1 atropine to patients in neostigmine group (Group N). Intraoperative and postoperative hemodynamic changes, extubation times, time to reach TOF 90%, recovery times, and complications were recorded. Results: The time of TOF 90%, onset of spontaneous respiration, and extubation times after antidote administration were found to be significantly lower in group S. No significant difference was found between the groups in postoperative complications. Conclusion: In the present study conducted in infants, in Group S, the use of sugammadex as an antidote provided both rapid reversal compared to neostigmine, and similar adverse effects were observed, which is consistent with the literature.