JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.28, no.6, pp.1205-1210, 2013 (SCI-Expanded)
Article / Article
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Antidiabetic drugs, 2,4-thiazolidinediones, imidazolidine-2,4-diones, 2-thioxo-imidazolidine-4-ones, chromonyl-2,4-thiazolidinediones, insulinotropic activity, HYPOGLYCEMIC ACTIVITY, FLAVONE DERIVATIVES, THIAZOLIDINEDIONES, COMMUNICATION, CHROMONYL-2,4-THIAZOLIDINEDIONES, THERAPY
Ondokuz Mayıs University Affiliated:
Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, we report the synthesis and the in vitro insulin releasing activity of the 6-methyl-chromonyl-2,4-thiazolidinediones (IIIa-c, IVa-c, Va-c). Compounds IIIb, IIIc, IVa-c, Va and Vc (at lower concentration; 0.001 mg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose. In this series, the most potent compound is IVa having methyl group at N3 position of TZD ring.