The Use of Sequential VEGF- and BMP2-Releasing Biodegradable Scaffolds in Rabbit Mandibular Defects

Cakir-Ozkan N., EĞRİ S., Bekar E., Altunkaynak B. Z., Kabak Y. B., Kivrak E. G.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol.75, no.1, 2017 (SCI-Expanded) identifier identifier identifier


Purpose: Promising developments have materialized in reconstructive surgical procedures with the applications of tissue engineering. In our study, we used tissue scaffolds fabricated from polylactic acidpolyethylene glycol (PLLA-PEG) copolymers to ensure different release rates of selective growth factors recombinant human bone morphogenetic protein 2 [rhBMP-2] and vascular endothelial growth factor (rhVEGF165) in the repair of mandibular bone defects.