The Use of Sequential VEGF- and BMP2-Releasing Biodegradable Scaffolds in Rabbit Mandibular Defects

Cakir-Ozkan, Nilüfer; EĞRİ, SİNAN; Bekar, Esengul; Altunkaynak, B.; Kabak, Yonca; Kivrak, Elfide

doi:10.1016/j.joms.2016.08.020

The Use of Sequential VEGF- and BMP2-Releasing Biodegradable Scaffolds in Rabbit Mandibular Defects

Cakir-Ozkan N., EĞRİ S., Bekar E., Altunkaynak B. Z., Kabak Y. B., Kivrak E. G.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, cilt.75, sa.1, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 75 Sayı: 1
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.joms.2016.08.020
Dergi Adı: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Purpose: Promising developments have materialized in reconstructive surgical procedures with the applications of tissue engineering. In our study, we used tissue scaffolds fabricated from polylactic acidpolyethylene glycol (PLLA-PEG) copolymers to ensure different release rates of selective growth factors recombinant human bone morphogenetic protein 2 [rhBMP-2] and vascular endothelial growth factor (rhVEGF165) in the repair of mandibular bone defects.