Clinically informative microRNAs for SARS-CoV-2 infection

Ergün S., Sankaranarayanan R., Petrovic N.

EPIGENOMICS, cilt.15, sa.13, ss.705-716, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 13
  • Basım Tarihi: 2023
  • Doi Numarası: 10.2217/epi-2023-0179
  • Dergi Adı: EPIGENOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.705-716
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

COVID-19 is a viral respiratory infection induced by the newly discovered coronavirus SARS-CoV-2. miRNA is an example of a strong and direct regulator of a gene's transcriptional activity. The interaction between miRNAs and their target molecules is responsible for homeostasis. Virus-derived and host-derived miRNAs are involved in the activity of hiding from immune system cells, inducing the inflammatory reaction through interplay with associated genes, during SARS-COV-2 infection. Interest in miRNAs has raised the comprehension of the machinery and pathophysiology of SARS-COV-2 infection. In this review, the effects and biological roles of miRNAs on SARS-CoV-2 pathogenicity and life cycle are described. The therapeutic potential of miRNAs against SARS-CoV-2 infection are also mentioned. Small regulatory nucleic acids, miRNAs, may provide diagnostic and therapeutic potential for COVID-19.