Study for the Diagnostic Screening of Paroxysmal Nocturnal Hemoglobinuria in Older Patients with Unexplained Anemia and/or Cytopenia

Ozdemir Z. N., Ilhan O., Ozet G., Falay M., Yenerel M., Tuglular T., ...More

CLINICAL LABORATORY, vol.66, no.9, pp.1709-1715, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 9
  • Publication Date: 2020
  • Doi Number: 10.7754/clin.lab.2020.191218
  • Journal Name: CLINICAL LABORATORY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.1709-1715
  • Keywords: paroxysmal nocturnal hemoglobinuria, older patients, multiparameter flow cytometry, consensus based clinical indications, PIG-A MUTATIONS, MYELODYSPLASTIC SYNDROMES, PNH, GUIDELINES, DISORDERS, CLONES, ADULTS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disease that may lead to weakness and death of patients, if unrecognized and untreated. Although consensus guidelines were reviewed recently for the diagnostic screening of PNH with multi-parameter flow cytometry (FCM), until now, no study has investigated the efficiency of such clinical indications in older patients.