Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay

KOÇ A., SİLİCİ S., Ayangil D., Ferahbaş A., Çankaya S.

Mycoses, vol.48, no.3, pp.205-210, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1439-0507.2005.01128.x
  • Journal Name: Mycoses
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.205-210
  • Keywords: Antifungal activity, Antifungal agents, Dermatophytes, Microdilution method, Propolis
  • Ondokuz Mayıs University Affiliated: No


The in vitro activities of propolis against 29 strains of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, and fluconazole. Minimal inhibitory concentrations (MICs) were determined according to a National Committee for Clinical Laboratory Standards broth microdilution method. Among the systemic antifungals tested, terbinafine was the most potent. Propolis showed important antifungal activity and it merits further investigation as a potentially useful agent for the treatment of dermatophytosis. © 2005 Blackwell Publishing Ltd.