The absence of insulin resistance in metabolic syndrome definition leads to underdiagnosing of metabolic risk in obese patients

Kurtoglu S., Akin L., Kendirci M., HATİPOĞLU N., Elmali F., MAZICIOĞLU M. M.

European Journal of Pediatrics, vol.171, no.9, pp.1331-1337, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 171 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1007/s00431-012-1724-6
  • Journal Name: European Journal of Pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1331-1337
  • Keywords: Adolescent, Children, IDF definition, Insulin resistance, Metabolic syndrome
  • Ondokuz Mayıs University Affiliated: No


This study explores in a group of obese children and adolescents aged 10 to16 years, the prevalence of metabolic syndrome (MS) according to the criteria of International Diabetes Federation (IDF). In addition, the prevalence of insulin resistance (IR) was investigated to find correlations between MS and IR. IDF definition was compared to a modified WHO definition. A total of 159 obese patients (74 male and 85 female; median age 12.7 years) were included in the study. Anthropometric measurements, blood pressure, and serum fasting lipids were evaluated. An oral glucose tolerance test (OGTT) was performed, and serum glucose and insulin levels were measured at 0, 30, 60, 90, and 120 min. Homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), fasting glucose/insulin ratio (FGIR), Matsuda index, and total insulin levels during OGTTwere calculated. For the IR diagnosis, we used cutoff values described in previous publications (HOMA-IR of >3.16, QUICKI of <0.357, FGIR of <7, and/ or the sum of insulin levels during OGTT of >300 mIU/mL). MSprevalence, defined according to IDF criteria, was 34.6 %. Using the IDF definition, there was no statistically significant difference for the surrogate IR indices between patients with or without MS (QUICKI, 94.5 vs. 83.7 %), FGIR (81.1 vs. 78.8 %), HOMA-IR (70.9 vs. 63.5 %), and total insulin levels during OGTT (61.8 vs. 51.9 %). The Matsuda index values, the prevalence of fasting hyperinsulinemia, and impaired glucose tolerance were also similar in these two groups. In conclusion, IR was prominent in obese patients with and withoutMS. IDF definition ofMS fails to discover individuals with IR, unless it is specifically investigated. © Springer-Verlag 2012.