An unconditioned bone marrow transplantation in a child with purine nucleoside phosphorylase deficiency and its unique complication

Aytekin C., Yuksek M., DOĞU E. F., Yagmurlu A., YILDIRAN AVCU Y., FİTOZ Ö. S., ...Daha Fazla

PEDIATRIC TRANSPLANTATION, sa.4, ss.479-482, 2008 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1111/j.1399-3046.2007.00890.x
  • Dergi Adı: PEDIATRIC TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.479-482
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Purine nucleoside phosphorylase deficiency is a rare immunodeficiency syndrome characterized by recurrent infections, neurological dysfunction, and autoimmunity. Early diagnosis and hematopoietic stem cell transplantation may reverse the dismal prognosis in PNP deficiency. This report presents a new PNP deficiency case successfully transplanted without a conditioning regimen from an HLA-identical family donor, who developed a complication of disseminated BCG infection.