The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.47, no.1, pp.103-111, 2022 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 47 Issue: 1
- Publication Date: 2022
- Doi Number: 10.1515/tjb-2021-0086
- Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Page Numbers: pp.103-111
- Keywords: axial spondyloarthritis, disease risk, inflammation, peroxisome proliferator activated receptor alpha, polymorphism, PROLIFERATOR-ACTIVATED RECEPTOR, PROTEIN, MUTATIONS, RECOGNITION, PREVALENCE, MECHANISMS, SERVER, GENE
- Open Archive Collection: AVESIS Open Access Collection
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Objectives: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investigate the relationship of NG_012204.2:p.A1a268Val polymorphism of PPARA with axSpA risk and its role in disease development.