Effects of bisphosphonate treatment on mandibular condyle tissues of temporomandibular joint: A stereological study

GÖNEN Z. B., Colpak H. A., Onger M. E.

JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY, vol.120, no.6, pp.513-516, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 120 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jormas.2019.04.003
  • Journal Name: JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.513-516
  • Keywords: Bisphosphonate, Zoledronic acid, Temporomandibular joint, Mandibular condyle, Stereological study, BONE, CARTILAGE, ALENDRONATE, EXPRESSION, SYNOVIUM, VEGF
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Introduction: Although the adverse effects due to the use of bisphosphonates, such as bisphosphonate-induced osteonecrosis of the jaw, are reported previously, whether adverse events of the temporomandibular joint related with bisphosphonate treatment have been still unclear. Therefore, the aim of this study is to evaluate the effects of BP treatment on the condylar tissues of the temporomandibular joint due to fibrous cartilage, hyaline cartilage and bone-specific differences in rat animal models.