Synthesis of alpha-Ketothioamides via Willgerodt-Kindler Reaction of Arylglyoxals with Amines and Sulfur under Solvent-Free Conditions

Eftekhari-Sis B., Khajeh S. V., Buyukgungor O.

SYNLETT, cilt.24, sa.8, ss.977-980, 2013 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 8
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1055/s-0032-1316897
  • Dergi Adı: SYNLETT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
  • Sayfa Sayıları: ss.977-980
  • Anahtar Kelimeler: alpha-ketothioamides, Willgerodt-Kindler reaction, arylglyoxals, green chemistry, solvent-free, CONJUGATE ADDITION, KINETIC RESOLUTION, THIOAMIDES, THIONATION, EFFICIENT, FACILE, CYCLIZATION, THIOPHENES, SUBSTRATE, CATALYST
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Willgerodt-Kindler reaction of arylglyoxal hydrates with secondary amines and elemental sulfur under solvent-free conditions at 80 degrees C is developed, in which alpha-ketothioamides are obtained in 70-90% yield in 0.6-1 hour. The X-ray crystal-structure analysis for one compound was obtained.