Synthesis of alpha-Ketothioamides via Willgerodt-Kindler Reaction of Arylglyoxals with Amines and Sulfur under Solvent-Free Conditions
SYNLETT, cilt.24, sa.8, ss.977-980, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 8
- Basım Tarihi: 2013
- Doi Numarası: 10.1055/s-0032-1316897
- Dergi Adı: SYNLETT
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
- Sayfa Sayıları: ss.977-980
- Anahtar Kelimeler: alpha-ketothioamides, Willgerodt-Kindler reaction, arylglyoxals, green chemistry, solvent-free, CONJUGATE ADDITION, KINETIC RESOLUTION, THIOAMIDES, THIONATION, EFFICIENT, FACILE, CYCLIZATION, THIOPHENES, SUBSTRATE, CATALYST
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Willgerodt-Kindler reaction of arylglyoxal hydrates with secondary amines and elemental sulfur under solvent-free conditions at 80 degrees C is developed, in which alpha-ketothioamides are obtained in 70-90% yield in 0.6-1 hour. The X-ray crystal-structure analysis for one compound was obtained.