Evaluation of hepatoprotective activity of Bergamot orange in rats

Karaca M., Ilhan F., Altan H., Him A., Tütüncü M., Özbek H.

Eastern Journal of Medicine, vol.10, no.1-2, pp.1-4, 2005 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 1-2
  • Publication Date: 2005
  • Journal Name: Eastern Journal of Medicine
  • Journal Indexes: Scopus
  • Page Numbers: pp.1-4
  • Keywords: Bergamot orange, Carbon tetrachloride, Hepatoprotective activity, Rats
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Essential oil extract of Bergamot orange (BO) was investigated for its hepatoprotective effect on carbon tetrachloride-induced hepatotoxicity in rats. Six different groups were established. Silibinin was used as the reference agent. BO significantly reduced the serum ALT level when compared to CCl 4 group while it did not affect the serum AST level. The histopathological findings did not show any significant difference between the BO and CCl 4 groups. The results suggest that BO has a weak hepatoprotective effect in carbon tetrachloride induced acute liver toxicity.