The effects of ovariectomy and naproxen treatment on the strength of femoral midshaft and molar alveolar region in rats efectos de la ovariectomía y tratamiento con naproxeno sobre la resistencia de la parte media de la diáfisis femoral y la región alveolar molar en ratas

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Turkozan N., Ulusoy A., Balcioglu H., Bal F., Ozel S.

International Journal of Morphology, vol.27, no.3, pp.659-666, 2009 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.4067/s0717-95022009000300007
  • Journal Name: International Journal of Morphology
  • Journal Indexes: Scopus
  • Page Numbers: pp.659-666
  • Keywords: Bone mineral density, Maximum load, Naproxen, Ovariectomy
  • Ondokuz Mayıs University Affiliated: Yes


The goal of the present study was to investigate the effects of ovariectomy and naproxen treatment on both femoral and mandibular bone mass and biomechanical competence. Sprague-Dawley rats were used and divided into five groups: baseline, sham ovariectomized, ovariectomized, sham ovariectomized + naproxen treatment, ovariectomized + naproxen treatment. Mandibles and femurs of the rats were extracted and bone mineral density of the extracted specimens were determined. The volumes and ash weights of the femurs and mandibles were estimated. Maximum loads of the femurs and mandibles were determined by using a three point bending test. Ovariectomy decreased bone mineral density of the femoral midshaft, however naproxen prevented this decrease. Neither ovariectomy nor naproxen treatment affected the BMD in the molar alveolar region. Maximum load was found significantly decreased in the femoral midshaft, however, naproxen treatment prevented this decrease. Maximum load of the molar alveolar region did not significantly change. Naproxen prevents the strength characteristics of femoral midshaft afforded by ovariectomy. However, neither ovariectomy nor naproxen has an effect on the molar alveolar region of the mandible.