Serum 1,25 dihydroxy vitamin D (1,25(OH)<sub>2</sub>D<sub>3</sub>), 25 hydroxy vitamin D (25(OH)D) and parathormone levels in diabetic retinopathy


Aksoy H., Akçay F., Kurtul N., Baykal O., Avcı B.

CLINICAL BIOCHEMISTRY, vol.33, no.1, pp.47-51, 2000 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 1
  • Publication Date: 2000
  • Doi Number: 10.1016/s0009-9120(99)00085-5
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.47-51
  • Ondokuz Mayıs University Affiliated: No

Abstract

Objectives: To investigate whether there is a relationship between serum 1,25 dihydroxy vitamin D-3 [1,25(OH)(2)D-3] which is an inhibitor of angiogenesis, concentrations and severity of diabetic retinopathy (DR). Design and methods: Serum 1,25(OH)(2)D-3, 25 hydroxy vitamin D [25(OH)D] and parathormone (PTH) concentrations were measured in diabetic patients (n = 66) and nondiabetic healthy subjects (n = 20). Results: The mean serum 1,25(OH)(2)D-3 concentration in diabetic patients was lower than that in nondiabetics (57.3 +/- 21.44 vs 89.4 +/- 18.01 pmol/L, p < 0.001); mean 1,25(OH)(2)D-3 concentrations fell with increasing severity of DR [being 63.4 +/- 17.26 pmol/L for background DR (BDR), 47.7 +/- 13.27 pmol/L for preproliferative DR (pre-PDR), and 43.1 +/- 19.45 pmol/L for proliferative DR (PDR)]. Compared with the control group, serum 25(OH)D concentrations were found to be decreased in diabetic patients (p < 0.001). There were negative correlations between 1,25(OH)(2)D-3 and age (r = -0.331, p < 0.01) and duration of diabetes (r = -0.255, p < 0.05). Conclusion: From these findings, it was found that there was an inverse relationship between the severity of the retinopathy, i.e., neovascularization, and serum 1,25(OH)(2)D-3 concentrations, being the lowest in PDR and the highest in diabetic patients without retinopathy (NDR) patients. The measurement of serum 1,25(OH)(2)D-3 concentrations might be helpful to predict severity of DR in patients with diabetes mellitus. Copyright (C) 2000 The Canadian Society of Clinical Chemists.