Relationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever

Coşkun U. S. Ş., Yiğit S., Aci R., Tural E., Bozkurt N., Barut H. Ş.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, cilt.71, sa.7, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71 Sayı: 7
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1590/1806-9282.20250147
  • Dergi Adı: REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

OBJECTIVE: This study aims to investigate the relationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever METHODS: A total of 130 serum samples were analyzed, including 60 patients diagnosed with Crimean-Congo hemorrhagic fever and 70 healthy controls. Genetic analyses were performed using polymerase chain reaction and restriction fragment length polymorphism techniques. RESULTS: Significant differences were observed between patient and control groups in terms of vascular endothelial growth factor -460 C/T and -ID (18 bp) polymorphisms. CONCLUSION: Vascular endothelial growth factor gene polymorphisms may contribute to genetic susceptibility to Crimean-Congo hemorrhagic fever. Further studies with larger sample sizes are recommended to support these findings.