Relationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever

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Coşkun U. S. Ş., Yiğit S., Aci R., Tural E., Bozkurt N., Barut H. Ş.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, vol.71, no.7, 2025 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 71 Issue: 7
• Publication Date: 2025
• Doi Number: 10.1590/1806-9282.20250147
• Journal Name: REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
• Ondokuz Mayıs University Affiliated: Yes

Abstract

OBJECTIVE: This study aims to investigate the relationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever METHODS: A total of 130 serum samples were analyzed, including 60 patients diagnosed with Crimean-Congo hemorrhagic fever and 70 healthy controls. Genetic analyses were performed using polymerase chain reaction and restriction fragment length polymorphism techniques. RESULTS: Significant differences were observed between patient and control groups in terms of vascular endothelial growth factor -460 C/T and -ID (18 bp) polymorphisms. CONCLUSION: Vascular endothelial growth factor gene polymorphisms may contribute to genetic susceptibility to Crimean-Congo hemorrhagic fever. Further studies with larger sample sizes are recommended to support these findings.