Relationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, cilt.71, sa.7, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 71 Sayı: 7
- Basım Tarihi: 2025
- Doi Numarası: 10.1590/1806-9282.20250147
- Dergi Adı: REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
OBJECTIVE: This study aims to investigate the relationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever METHODS: A total of 130 serum samples were analyzed, including 60 patients diagnosed with Crimean-Congo hemorrhagic fever and 70 healthy controls. Genetic analyses were performed using polymerase chain reaction and restriction fragment length polymorphism techniques. RESULTS: Significant differences were observed between patient and control groups in terms of vascular endothelial growth factor -460 C/T and -ID (18 bp) polymorphisms. CONCLUSION: Vascular endothelial growth factor gene polymorphisms may contribute to genetic susceptibility to Crimean-Congo hemorrhagic fever. Further studies with larger sample sizes are recommended to support these findings.