Evaluation of gingival alterations in rats medicated with cyclosporine A, tacrolimus and sirolimus: a stereological study

Pamuk F., Cetinkaya B. O., Ayas B., Keles G. C., Gacar A.

JOURNAL OF PERIODONTAL RESEARCH, vol.50, no.5, pp.629-636, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.1111/jre.12243
  • Journal Name: JOURNAL OF PERIODONTAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.629-636
  • Keywords: animal model, cyclosporine A, gingival overgrowth, sirolimus, tacrolimus, RENAL-TRANSPLANT RECIPIENTS, MTOR INHIBITION, RISK-FACTORS, OVERGROWTH, RAPAMYCIN, PREVALENCE, THERAPY, IMMUNOSUPPRESSANTS, ENLARGEMENT, CONVERSION
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background and ObjectiveIt has previously been shown that both cyclosporine A and tacrolimus cause gingival overgrowth in the rat. We proposed that sirolimus may play an important role in decreasing the severity of gingival overgrowth. Therefore, the aim of this study was to evaluate the gingival changes induced by immunosuppressants, in the presence and absence of sirolimus, using histopathology and stereological methods.