JOURNAL OF PERIODONTAL RESEARCH, vol.50, no.5, pp.629-636, 2015 (SCI-Expanded)
Article / Article
JOURNAL OF PERIODONTAL RESEARCH
Science Citation Index Expanded (SCI-EXPANDED), Scopus
animal model, cyclosporine A, gingival overgrowth, sirolimus, tacrolimus, RENAL-TRANSPLANT RECIPIENTS, MTOR INHIBITION, RISK-FACTORS, OVERGROWTH, RAPAMYCIN, PREVALENCE, THERAPY, IMMUNOSUPPRESSANTS, ENLARGEMENT, CONVERSION
Ondokuz Mayıs University Affiliated:
Background and ObjectiveIt has previously been shown that both cyclosporine A and tacrolimus cause gingival overgrowth in the rat. We proposed that sirolimus may play an important role in decreasing the severity of gingival overgrowth. Therefore, the aim of this study was to evaluate the gingival changes induced by immunosuppressants, in the presence and absence of sirolimus, using histopathology and stereological methods.