Proteomic Analysis of a hom-Disrupted, Cephamycin C Overproducing Streptomyces clavuligerus
PROTEIN AND PEPTIDE LETTERS, cilt.28, sa.2, ss.205-220, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.2174/0929866527666200723163655
- Dergi Adı: PROTEIN AND PEPTIDE LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
- Sayfa Sayıları: ss.205-220
- Anahtar Kelimeler: Cephamycin C, Streptomyces clavuligerus, hom-disruption, proteomics, MALDI-TOF/MS, nanoLC-MS/MS, CLAVULANIC ACID PRODUCTION, SECONDARY METABOLISM, HETEROLOGOUS EXPRESSION, ANTIBIOTIC PRODUCTION, BIOSYNTHETIC GENES, DEHYDROGENASE GENE, CRYSTAL-STRUCTURE, TETR FAMILY, SYSTEM, COELICOLOR
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Background: Streptomyces clavuligerus is prolific producer of cephamycin C, a medically important antibiotic. In our former study, cephamycin C titer was 2-fold improved by disrupting homoserine dehydrogenase (hom) gene of aspartate pahway in Streptomyces clavuligerus NR-RL 3585.