Evaluation of Antinociceptive and Neurotoxic Effects of Intrathecal Dexmedetomidine in Rats

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Isguzar O., Barış S., Bozkurt A., Can Meydan B., Bilge S. S., Ture H.

BALKAN MEDICAL JOURNAL, vol.29, no.4, pp.354-357, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.5152/balkanmedj.2012.034
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.354-357
  • Keywords: Dexmedetomidine, intrathecal, neurotoxicity, histopathology, rat, SPINAL-CORD, CLONIDINE, ANTAGONIST, AGONIST, BUPIVACAINE, ANALGESIA, EFFICACY, PAIN
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: Dexmedetomidine has been reported to produce analgesia after intrathecal administration. In the present study the alpha 2-adrenoceptor agonist dexmedetomidine was evaluated for its potential spinal neurotoxic effects.