Antimicrobial Activity of Essential Oil Components and Antiproliferative Activity of Trans-Tiliroside Compound from an Endemic Desert Species <i>Thymelaea microphylla</i> Coss. et Dur.

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Noman L., Zellagui A., Yaglioglu A. S., Demirtaş İ., Salah R.

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, no.2, pp.671-676, 2015 (ESCI)

• Publication Type: Article / Article
• Publication Date: 2015
• Journal Name: RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES
• Journal Indexes: Emerging Sources Citation Index (ESCI)
• Page Numbers: pp.671-676
• Ondokuz Mayıs University Affiliated: No

Abstract

Essential oil components of the aerial parts of Thymelaea microphylla was subjected to evaluate the antimicrobial activity by disc diffusion method and tested against Gram-positive and Gram-negative bacteria and showed a high antibacterial activity against E. coli and Staphylococcus aureus at 2000 mu g /ml. The antiproliferative activity of fraction (7) from Thymelaea microphylla showed significant inhibitory activity on HeLa cells and moderate antiproliferative activity of trans-tiliroside compound was investigated in vitro on HeLa cells (human uterus carcinoma) activity and C6 cells (rat brain tumor).