Association between surfactant protein B gene locus and acute bronchiolitis in infants
CUKUROVA MEDICAL JOURNAL, vol.47, no.4, pp.1440-1446, 2022 (ESCI, TRDizin)
- Publication Type: Article / Article
- Volume: 47 Issue: 4
- Publication Date: 2022
- Doi Number: 10.17826/cumj.1124468
- Journal Name: CUKUROVA MEDICAL JOURNAL
- Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Page Numbers: pp.1440-1446
- Keywords: Acute bronchiolitis, genetic polymorphism, SFTPB gene, surfactant protein, SP-A, POLYMORPHISMS, DISEASE
- Open Archive Collection: AVESIS Open Access Collection
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Purpose: The aim of this study was to investigate whether there is a relationship between surfactant protein B (SFTPB) C1580T polymorphism and acute bronchiolitis. Materials and Methods: The study analyzed the allele frequency and genotype distribution for the SFTPB C1580T polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 103 acute bronchiolitis infants and 102 healthy infants. Results: The results showed no association between SFTPB C1580T polymorphism and clinical characteristics of acute bronchiolitis. The distribution of the CT genotype was higher in acute bronchiolitis infants (43%) than in healthy subjects (39%) and distribution of the TT genotype was found lower in acute bronchiolitis infants (38%) than in healthy subjects (41%). No significant differences in genotype distribution and allele frequency for the SFTPB C1580T polymorphism were found between case group and control group Conclusion: SFTPB C1580T gene polymorphism plays no important role in susceptibility to acute bronchiolitis. Further work on the relevance of SFTPB C1580T polymorphism in larger cohorts will require validating our results.