A micro-sized PVC membrane Li+-selective electrode without internal filling solution and its medical applications

ÇOLDUR F., Andaç M., IŞILDAK İ., Saka T.

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, vol.626, no.1-2, pp.30-35, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 626 Issue: 1-2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jelechem.2008.10.029
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.30-35
  • Keywords: Li+-selective electrode without inner reference solution, Blood serum analysis, Pharmaceutical formulations, Solid-state contact, Potentiometric analysis, CARBON-PASTE ELECTRODE, ION-CHROMATOGRAPHY, POTENTIOMETRIC DETECTION, MONOVALENT ANIONS, SENSOR ARRAY, CROWN-ETHERS, LITHIUM, INJECTION, DERIVATIVES, IONOPHORES
  • Ondokuz Mayıs University Affiliated: Yes


A micro-sized polyvinyl chloride (PVC) membrane Li+-selective electrode without inner filling solution was constructed. The emf measurements were made by using a micro-sized solid silver/silver chloride reference electrode. The potentiometric response characteristics of the electrode were examined under steady-state conditions. The developed electrode showed high selectivity for lithium with respect to common alkali and alkaline-earth metal cations. The working concentration range of the electrode was 1.0 x 10(-1) to 6.0 x 10(-5) mol L-1 with a slope of 53.6 mV decade(-1), and pH working range was found to be 6-10. The electrode had a very short response time (<10 s) and good reproducibility. There was no significant change in the slope of the concentration-potential curve during the usage period of 10 weeks. The developed electrode was utilized for the determination of lithium contents of human blood serum samples and pharmaceutical formulations in steady-state conditions. The obtained potentiometric results for both serum samples and pharmaceutical formulations are in good agreement with atomic emission spectrophotometry (AES) results at the 95% confidence level. (C) 2008 Elsevier B.V. All rights reserved.