Premature ovarian failure and 46,X,del(X)(q21) Prematüre ovaryen yetmezlik ve 46,X,del(X)(q21)
Ondokuz Mayis Universitesi Tip Dergisi, cilt.29, sa.2, ss.167-168, 2012 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 2
- Basım Tarihi: 2012
- Doi Numarası: 10.5835/jecm.omu.29.02.018
- Dergi Adı: Ondokuz Mayis Universitesi Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.167-168
- Anahtar Kelimeler: Amenorrhea, Chromosomal aberration, Cytogenetics, Female infertility, Premature ovarian failure, X chromosome deletion
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Premature ovarian failure (POF) is a common cause of infertility in women, and is characterised by amenorrhoea, hypo-oestrogenism and elevated gonadotrophin levels in women under the age of 40. Genetic, autoimmune and the environmental factors play a role in the pathogenesis. In this study, we investigated a 22 year-old woman having premature ovarian failure, referred to our laboratuary from Ondokuz Mayis University Gynecology and Obstetrics polyclinic. In conventional cytogenetic analysis, a deletion was observed in the long arm of the X chromosome 46,X,del(X)(q21). This finding was emphasised once again the significance of X chromosome deletions in the premature ovarian failure. © 2012 OMU.