Ranitidine and somatostatin for prophylaxis of stress ulcer in rats

Rizalar R., Sarac A., Gork S., Barış S., Bernay F., Gurses N.

Turkish Journal of Medical Sciences, vol.24, no.4, pp.301-303, 1995 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 4
  • Publication Date: 1995
  • Journal Name: Turkish Journal of Medical Sciences
  • Journal Indexes: Scopus
  • Page Numbers: pp.301-303
  • Keywords: ranitidine, somatostatin, stress ulcer
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

The effects of somatostatin and ranitidine on prophylaxis of stress ulcer are compared using three experimental groups of rats: Sham group, ranitidine group, and somatostatin group. Gastric mucosal damage index was measured in each group and Mann-Whitney U test was used for statistical analysis. Statistically, there was not any difference between the sham and the ranitidine groups (p > 0.05), but the mucosal damage index in the somatostatin group was significantly lower then in the sham and the ranitidine groups (p < 0.01). Somatostatin seems to be a more effective drug than ranitidine for the prophylaxis of stress ulcers.