Objective: This study had been carried out to investigate the effects of intramuscular daily single dose antibiotic treatment during five days in the outpatient clinics in children having lower UTI and to observe the effects to the disease course in infants and toddlers. Methodology: 36 children (12 boys) at the ages of between 5-68 months were enrolled into the study. Regarding the antibiogram suitability, single dose ceftriaxon or amikacin is prescribed to the patients for five days. Result In the urine cultures E. Coli was most commonly isolated. There was correlation between leukocytosis and insufficient weight gain (p<0.05). A correlation was also noted between recurrence of the disease and urinary tract abnormalities detected on the ultrasonography (p<0.05). Reenfection were detected in 1 of the infants and in 2 of the older children. There was no correlation between the recurrence and the therapy given. Conclusion: We consider that five-day intramuscular antibiotic therapy could be effective in the treatment of lower UTI and it can be recommended as a safe treatment modality in patients representing unwillingness to come to follow-up visits.