Research Information System
Online Türk Sağlık Bilimleri Dergisi, vol.6, no.3, pp.327-332, 2021 (Peer-Reviewed Journal)
Objective: Although connexins are thought to providenormally functioning gap junctions via a tumor suppressorgene, new studies point to an abnormal increase of connexins in various carcinomas and sarcomas. Therefore itwas aimed to investigate the expression of connexin 43(Cx43) and connexin 32 (Cx32) in adenomatous and hyperplastic polyps.Materials and Methods: This retrospective studyincluded 32 cases with adenomatous polyps and 42 caseswith hyperplastic polyps, between 2014 and 2015. Thesamples were stained with immunohistochemical stainingmethod with Cx43 and Cx32 and evaluated.Results: In our study, we observed that Cx43 and Cx32staining increased in hyperplastic polyps compared to adenomatous polyps (p=0.039, p=0.048 respectively). Statistically, there were no significant correlations between age,sex, location, and diameter with staining pattern.Conclusion: Loss of Cx43 and Cx32 staining in adenomatous polyps was noted and thought to be related to dysplasia