Significance of <i>IL</i>-<i>1Ra</i> and <i>IL</i>-<i>6</i> gene variants in Turkish patients with Crimean-Congo hemorrhagic fever
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE, sa.2, ss.85-90, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2019
- Doi Numarası: 10.4103/2221-1691.250864
- Dergi Adı: ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.85-90
- Anahtar Kelimeler: -572GC, -597GA, Crimean-Congo hemorrhagic fever, IL-1Ra, IL-6, Variable number of tandem repeat
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Objective: To investigate the association between IL-IRa variable number of tandem repeat (rs2234663), IL-6 -597GA (rs1800797), IL-6 -572GC (rs1800796) and the risk of Crimean-Congo hemorrhagic fever (CCHF) in the Turkish patients. Methods: This study included 50 patients infected with CCHF and 50 healthy controls. These variants were genotyped using polymerise chain reaction and/or restriction fragment length polymorphism method. Results: The distribution of the IL-6 -572GC genotypes and alleles varied significantly between the patients and the controls. The subjects carrying IL-6 -572GC GG genotype and G allele had increased risk of developing CCHF compared to the control group (P=0.006, P=0.014, respectively). IL-6 -572GC GC genotype was higher in the controls than the patients (P=0.006). For the triple genotype combinations, the 1/2-GC-GO genotype combination was detected more frequently in the control group than CCHF patients (P=0.016). IL-6 (-5721-597) GG-GG genotype was significantly higher in the patient group (P=0.015), while the GC-GG genotype was significantly lower in the patient group (P=0.005). Additionally, the G-G haplotype was significantly higher in the patient group (P=0.042), whereas C-G was found to be significantly lower in the patients than the control group (P=0.037). Conclusions: The results of this study suggest the IL-6 -572GC variant might be genetic markers of sensitivity to CCHF in the Turkish population and may facilitate greater protection against the disease.