Toll-like receptors; integrate innate and adaptive immunity, promise innovative therapies

Yıldıran A., İkincioğullari A.

Journal of Pediatric Infectious Diseases, cilt.1, sa.4, ss.195-203, 2006 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1 Sayı: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1055/s-0035-1557097
  • Dergi Adı: Journal of Pediatric Infectious Diseases
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.195-203
  • Anahtar Kelimeler: Innate immunity, NLR, Toll-like receptors
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Innate component of immunity is a skilful system that senses invading microbial pathogens and integrates to adaptive immunity by Toll-like receptors (TLRs). Another function of TLRs is to work in sterile inflammation to ligands derived from damaged cells, which are not usually present in the extracellular environment. Thus, TLRs have very important interferences in the pathogenesis of inflammatory and immune diseases. The discovery of TLRs has transformed our approach to immunology and related diseases. © 2006 - IOS Press and the authors.