Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats

Kaya A. H., Vlamings R., Tan S., Lim L. W., Magill P. J., Steinbusch H. W. M., ...Daha Fazla

BRAIN RESEARCH, cilt.1221, ss.93-97, 2008 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1221
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.brainres.2008.05.019
  • Dergi Adı: BRAIN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.93-97
  • Anahtar Kelimeler: Parkinson's disease, serotonin, dorsal raphe nucleus, subthalamic nucleus, HIGH-FREQUENCY STIMULATION, SUBSTANTIA-NIGRA, ANESTHETIZED RAT, NEURON ACTIVITY, BRAIN, DOPAMINE, 6-HYDROXYDOPAMINE, DISEASE, ADULT, RECEPTORS
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain. (C) 2008 Elsevier B.V. All rights reserved.