Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats

Kaya A. H., Vlamings R., Tan S., Lim L. W., Magill P. J., Steinbusch H. W. M., ...More

BRAIN RESEARCH, vol.1221, pp.93-97, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1221
  • Publication Date: 2008
  • Doi Number: 10.1016/j.brainres.2008.05.019
  • Journal Name: BRAIN RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.93-97
  • Keywords: Parkinson's disease, serotonin, dorsal raphe nucleus, subthalamic nucleus, HIGH-FREQUENCY STIMULATION, SUBSTANTIA-NIGRA, ANESTHETIZED RAT, NEURON ACTIVITY, BRAIN, DOPAMINE, 6-HYDROXYDOPAMINE, DISEASE, ADULT, RECEPTORS
  • Ondokuz Mayıs University Affiliated: No

Abstract

Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain. (C) 2008 Elsevier B.V. All rights reserved.