Oxidative Stress Induced by Ureteral Obstruction and Tadalafil

CIRRIK, SELMA; Ayyildiz, Sema; BENLİ, ERDAL; Ayyildiz, Ali; NOYAN, TEVFİK; Germiyanoğlu, Rüştü; ÇIRAKOĞLU, ABDULLAH

doi:10.5152/jarem.2017.1109

Oxidative Stress Induced by Ureteral Obstruction and Tadalafil

CIRRIK S., Ayyildiz S. N., BENLİ E., Ayyildiz A., NOYAN T., Germiyanoğlu R. C., ...Daha Fazla

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, cilt.7, sa.1, ss.11-15, 2017 (ESCI, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 7 Sayı: 1
Basım Tarihi: 2017
Doi Numarası: 10.5152/jarem.2017.1109
Dergi Adı: JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.11-15
Anahtar Kelimeler: PDE5, tadalafil, ureter, obstruction, oxidative stress, PHOSPHODIESTERASE TYPE 5, ISCHEMIA/REPERFUSION INJURY, INHIBITOR, EXPRESSION, RATS
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: It has been reported that tadalafil, a specific phosphodiesterase-5 (PDE5) inhibitor, has an antioxidant effect besides its well-known vasoactive properties. This study aimed to determine the possible protective effects of tadalafil in managing renal oxidative stress induced by unilateral ureteral obstruction (UUO).