Oxidative Stress Induced by Ureteral Obstruction and Tadalafil

CIRRIK S., Ayyildiz S. N., BENLİ E., Ayyildiz A., NOYAN T., Germiyanoğlu R. C., ...More

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, vol.7, no.1, pp.11-15, 2017 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.5152/jarem.2017.1109
  • Journal Name: JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.11-15
  • Keywords: PDE5, tadalafil, ureter, obstruction, oxidative stress, PHOSPHODIESTERASE TYPE 5, ISCHEMIA/REPERFUSION INJURY, INHIBITOR, EXPRESSION, RATS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: It has been reported that tadalafil, a specific phosphodiesterase-5 (PDE5) inhibitor, has an antioxidant effect besides its well-known vasoactive properties. This study aimed to determine the possible protective effects of tadalafil in managing renal oxidative stress induced by unilateral ureteral obstruction (UUO).