Atıf İçin Kopyala
Koksal M., Bilge S. S.
ARCHIV DER PHARMAZIE, cilt.340, sa.6, ss.299-303, 2007 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
340
Sayı:
6
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Basım Tarihi:
2007
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Doi Numarası:
10.1002/ardp.200700028
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Dergi Adı:
ARCHIV DER PHARMAZIE
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
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Sayfa Sayıları:
ss.299-303
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Anahtar Kelimeler:
antidepressant-like effect, aryl propane derivatives, forced swimming test, SSRI (selective serotonine reuptake inhibitors), substituted piperidine, DUAL 5-HT1A RECEPTOR, SEROTONIN TRANSPORTER AFFINITY, ANTAGONISM/SSRI ACTIVITIES, BIOLOGICAL EVALUATION, PART 5, 1-ARYLOXY-3-PIPERIDINYLPROPAN-2-OLS, SSRIS, DEPRESSION, DISCOVERY, MODEL
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Ondokuz Mayıs Üniversitesi Adresli:
Evet
Özet
This study describes the chemical synthesis and pharmacological evaluation of some new 1-aryl-3-[(4-benzyl)piperidine-1-yl]propane derivatives as antidepressants. The structures attributed to the compounds were elucidated using IR and H-1-NMR spectroscopic techniques besides elemental analysis. The antidepressant-like effect of these compounds was assessed by using the forced swimming test (FST), a validated experimental model of depression in mice. A clear antidepressant-like effect was shown for compounds 1, 2 and 4 by a significant decrease in immobility behaviour.