Synthesis and antidepressant-like profile of novel 1-aryl-3-[(4-benzyl)piperidine-1-yl]propane derivatives
ARCHIV DER PHARMAZIE, cilt.340, sa.6, ss.299-303, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 340 Sayı: 6
- Basım Tarihi: 2007
- Doi Numarası: 10.1002/ardp.200700028
- Dergi Adı: ARCHIV DER PHARMAZIE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Sayfa Sayıları: ss.299-303
- Anahtar Kelimeler: antidepressant-like effect, aryl propane derivatives, forced swimming test, SSRI (selective serotonine reuptake inhibitors), substituted piperidine, DUAL 5-HT1A RECEPTOR, SEROTONIN TRANSPORTER AFFINITY, ANTAGONISM/SSRI ACTIVITIES, BIOLOGICAL EVALUATION, PART 5, 1-ARYLOXY-3-PIPERIDINYLPROPAN-2-OLS, SSRIS, DEPRESSION, DISCOVERY, MODEL
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
This study describes the chemical synthesis and pharmacological evaluation of some new 1-aryl-3-[(4-benzyl)piperidine-1-yl]propane derivatives as antidepressants. The structures attributed to the compounds were elucidated using IR and H-1-NMR spectroscopic techniques besides elemental analysis. The antidepressant-like effect of these compounds was assessed by using the forced swimming test (FST), a validated experimental model of depression in mice. A clear antidepressant-like effect was shown for compounds 1, 2 and 4 by a significant decrease in immobility behaviour.