Lack of Association Between <i>MIF</i> Gene-173G>C Polymorphism with Multiple Sclerosis

Cevik B., Yiğit S., Karakus N., Aksoy D., Ates O., Kurt S.

IN VIVO, no.1, pp.71-76, 2015 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2015
  • Journal Name: IN VIVO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.71-76
  • Ondokuz Mayıs University Affiliated: No

Abstract

Aim: The aim of the present study was to investigate a possible association between the MIF -173G>C polymorphism and MS in Turkish patients. Materials and Methods: The study included 153 MS-patients and 210 controls. Genomic DNA was isolated and genotyped using PCR-RFLP assay for the MIF -173G>C promoter polymorphism (rs755622). Results: There was no statistically significant difference in allele and genotype frequencies between MS-patients and controls (p=0.227 and p=0.157, respectively). Accordingly, no association was observed when the patients were compared against controls in terms of GG versus GC+CC genotypes and GG+GC versus CC genotypes (p=0.324 and p=0.179, respectively). Also, there was no statistically significant association between MIF-173G>C polymorphism and clinical and demographic characteristics of MS-patients. Conlusion: The results of the present study suggest no relation between MS susceptibility and MIF gene 173G>C polymorphism in the examined Turkish population.