Synthesis and Determination of Some Biological Activities of Novel 2,4-Dinitrophenyl Derivatives

Sarikaya S. B. O., Kaya A. A., Çelenk Kaya E., Sentuerk M.

ARCHIV DER PHARMAZIE, cilt.348, sa.3, ss.214-220, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 348 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1002/ardp.201400330
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.214-220
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

The antioxidant and radical scavenging activities of the synthesized compounds 3, 5, and 6 were determined by various in vitro assays such as 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radical (ABTS(+)) scavenging, ferric ion (Fe3+) reducing power and ferrous ion (Fe2+) chelating activities. Moreover, these activities were compared to those of standard antioxidants such as butylated hydroxyanisole, butylated hydroxytoluene, and trolox. The results showed that the new compounds (3, 5, and 6) had potential antioxidant activity. Besides, inhibition of the two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I and II with some nitrobenzene compounds was investigated. Compounds 1-6 showed K-i values in the range of 4.88-193.4 mu M and 5.295-54.75 mu M for hCA I and hCA II, respectively.